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Current Edition

December 2017

Volume 3  Issue 1

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Research Article

Structural Characterization and Enzymatic Activity of the Recombinant Ala959 To Ser1066 Region of Human Ace

Caroline Cristina Eliasa, Larissa Miranda Pereira, Danielle S. Aragão, Dulce E. Casarini, Regina Affonso*

Angiotensin-converting enzyme catalyzes the conversion of angiotensin I to the vasoconstrictor angiotensin II and the hydrolysis of bradykinin (BK). Human somatic angiotensin-converting enzyme has two homologous domains (N and C) that share 60% identity. Although these two regions have high homology, the catalytic site of the C-domain exhibits three-fold greater activity than the N-domain in the hydrolysis of angiotensin I in vivo.

                                                                                                                                                                                                                         Full text   Download PDF

 

 

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